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Encephalopathy, Autoimmune Evaluation [A Test in Focus]

encephalopathy-brochure-buttonA new Encephalopathy autoimmune evaluation is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. Below is a short video overview from Andrew McKeon, M.D., discussing what providers should know about autoimmune encephalopathy, our testing approach, as well as interpretation, follow-up, and additional considerations once the test has been ordered.

testinfocus-test-info Similar Evaluations Include:

  • Many disorders of the central nervous system previously considered neurodegenerative and untreatable are now recognized as having an autoimmune cause.
  • Detection of one or more neural autoantibodies in serum or spinal fluid is consistent with a diagnosis of autoimmune encephalopathy
  • Autoimmune encephalopathy is not rare and is potentially treatable
  • Diagnosis is aided by testing autoantibody profiles in serum and spinal fluid
  • Occult cancer accompaniment is not uncommon
testinfocus-testutilization How to Use These Tests
As you consider autoimmune encephalopathy in the differential diagnosis, the following may be clues leading to an autoimmune cause and use of the autoantibody profiles.

  • Subacute onset of cognitive or other neuropsychiatric symptoms
  • Serological findings are diverse and cannot be predicted by neurological phenotype. Thus evaluating with profiles of autoantibodies is appropriate.
  • Subacute onset characterized by multimodal cognitive dysfunction with delirium or confusion
  • The major differential diagnostic consideration is central nervous system infection
  • Order profile ENCES (serum) or ENCEC (CSF)
  • ENCES — Serum
This entry was posted in A Test in Focus, Neuroimmunology, Neurology, Testing.

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