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Dementia, Autoimmune Evaluation [A Test in Focus]

A new dementia autoimmune evaluation is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. Below is a short video overview from Sean Pittock, M.D., discussing what providers should know about autoimmune dementia, our testing approach, as well as interpretation, follow-up, and additional considerations once the test has been ordered.

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testinfocus-test-info Similar Evaluations Include:

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  • Many disorders of the central nervous system previously considered neurodegenerative and untreatable are now recognized as having an autoimmune cause.
  • Detection of one or more neural autoantibodies in serum or spinal fluid is consistent with a diagnosis of autoimmune dementia
  • Autoimmune dementia is not rare and is potentially treatable
  • Diagnosis is aided by testing autoantibody profiles in serum and spinal fluid
  • Occult cancer accompaniment is not uncommon
testinfocus-testutilization How to Use These Tests
As you consider autoimmune dementia in the differential diagnosis, the following may be clues leading to an autoimmune cause and use of the autoantibody profiles.

  • Subacute onset of cognitive or other neuropsychiatric symptoms
  • Serological findings are diverse and cannot be predicted by neurological phenotype. Thus evaluating with profiles of autoantibodies is appropriate.
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  • Patients may have an isolated rapidly progressive dementia phenotype
  • May mimic rapidly progressive neurodegenerative disorders such as Creutzfeldt-Jakob disease, rapidly progressive diffuse Lewy Body disease, or other neurodegenerative disorders
  • Order profile DEMES (serum) or DEMEC (CSF)
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  • DEMEC — CSF
  • DEMES — Serum
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This entry was posted in Neuroimmunology, Neurology, Test in Focus, Testing.