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Analytical and Clinical Validation of an LC–MS/MS Method for Urine Leukotriene E4

Systemic mastocytosis is a disorder characterized by the abnormal accumulation of mast cells, which are typically responsible for allergic reactions. Mayo Clinic researchers hypothesized that urinary Leukotriene E4 could be used alone or in combination with N-methyl histamine and 11-beta prostaglandin F2α to optimize screening for systemic mastocytosis. In a recent study published in Clinical Biochemistry, the researchers describe a novel (LC–MS/MS) assay to accurately and precisely quantitate LTE4 in urine and outline its clinical utility in systemic mastocytosis screening.

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