Consortium Study of Dohner Hierarchical Classification of Chronic Lymphocytic Leukemia Reveals Improved Survival
Back in 2000, a German study guided by Hartmut Dohner, M.D., established the prognostic association of chromosome abnormalities identified by fluorescence in situ hybridization (FISH) analysis in patients with chronic lymphocytic leukemia (CLL). Since then, the “Dohner hierarchical classification” has been the gold standard by which clinicians in both academic and community settings treat and counsel their CLL patients. Now, more than 15 years later, a multi-institutional study, led by Mayo Clinic, revisited the Dohner hierarchy. Why? To learn if the original prognostic association still holds true. According to the new study, published in the British Journal of Haematology, this FISH hierarchy has indeed stood the test of time. Further, overall survival is now significantly longer in CLL patients—at least partly due to improved therapeutic options.
Recent Stories for Research
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews. This week’s roundup highlights a consortium study of Dohner hierarchical classification of chronic lymphocytic leukemia revealing improved survival.
T-lymphoblastic leukemia/lymphoma (also known as T-cell acute lymphoblastic leukemia or “T‑ALL”) is an aggressive cancer caused by an overproduction of immature T cells. Recent research suggests that the protein LMO2 appears to be a biomarker of transformed T‑precursor cells. In a recent study published in the American Journal of Clinical Pathology, Mayo Clinic researchers tested the specificity of LMO2 for distinction between neoplastic and non-neoplastic T-precursor cells in the thymus and bone marrow.
Other Posts for Research
- Mayo Clinic Laboratory and Pathology Research Roundup: April 18
- Preventing Unnecessary Blood Transfusions and Reducing Multiple-Donor Exposure among Premature Infants
- Mayo Clinic Laboratory and Pathology Research Roundup: April 11
- Mayo Clinic Laboratory and Pathology Research Roundup: April 4
- Testing for Vitamin D Toxicity
- Multiple Calibrator Measurements Improve Accuracy and Stability Estimates of Automated Assays
- Mayo Clinic Laboratory and Pathology Research Roundup: March 28
- Mayo Clinic Laboratory and Pathology Research Roundup: March 21
- Study Emphasizes Utility of MRI to Help Discriminate Long Myelitis of Neuromyelitis Optica from Sarcoidosis
- Analyzing the Effect of Gene Mutations in Chronic Myelomonocytic Leukemia on Overall Survival