Systemic mastocytosis is a disorder characterized by the abnormal accumulation of mast cells, which are typically responsible for allergic reactions. Mayo Clinic researchers hypothesized that urinary Leukotriene E4 could be used alone or in combination with N-methyl histamine and 11-beta prostaglandin F2α to optimize screening for systemic mastocytosis. In a recent study published in Clinical Biochemistry, the researchers describe a novel (LC–MS/MS) assay to accurately and precisely quantitate LTE4 in urine and outline its clinical utility in systemic mastocytosis screening.
Recent Stories for Research
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews. This week’s roundup highlights an analytical and clinical validation of an LC–MS/MS method for urine Leukotriene E4 in the diagnosis of systemic mastocytosis.
Lyme disease is the most commonly transmitted tick-borne infection in the United States. To test for Lyme disease, the Centers for Disease Control and Prevention, the National Institutes of Health, the Infectious Disease Society of America, and other health agencies endorsed the two-tiered testing algorithm (TTTA) in 1995. Today, this is still the most recommended testing. Elitza Theel, Ph.D., Director of the Infectious Diseases Serology Laboratory at Mayo Clinic in Rochester, wrote a review to discuss the evolution of serologic assays for Lyme disease and a summary of the performance characteristics for the recommended TTTA. Dr. Theel also analyzed a recently proposed alternative to the traditional TTTA and novel methodologies. The review was published in the Journal of Clinical Microbiology.
Other Posts for Research
- Mayo Clinic Laboratory and Pathology Research Roundup: May 16
- The Challenge of Celiac Disease Diagnosis
- Mayo Clinic Laboratory and Pathology Research Roundup: May 9
- Mayo Clinic Laboratory and Pathology Research Roundup: May 2
- Consortium Study of Dohner Hierarchical Classification of Chronic Lymphocytic Leukemia Reveals Improved Survival
- Mayo Clinic Laboratory and Pathology Research Roundup: April 25
- Assessing the Value of LMO2 as a Biomarker for T-Lymphoblastic Leukemia/Lymphoma
- Mayo Clinic Laboratory and Pathology Research Roundup: April 18
- Preventing Unnecessary Blood Transfusions and Reducing Multiple-Donor Exposure among Premature Infants
- Mayo Clinic Laboratory and Pathology Research Roundup: April 11