Coxiella burnetii (Q fever), Molecular Detection, PCR [A Test in Focus]


Robin Patel, M.D., chair of Mayo Clinic's Division of Microbiology, provides a three-minute overview of a new test for Coxiella burnetii, the causative agent of Q fever. Mayo Medical Laboratories has developed a real-time PCR test that rapidly detects Coxiella burnetii DNA in clinical specimens by targeting a sequence of the shikimate dehydrogenase gene (aroE) unique to Coxiella burnetii.

Below are some of the key aspects of the new test for your quick review. Also available for your reference is a detailed test information sheet.

 

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  • Diagnosing Coxiella burnetii infection (e.g., Q fever)
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  • Coxiella burnetii is the causative agent of Q fever.
  • Although infection generally causes mild respiratory disease, a small number of acute cases will advance to a chronic condition, which typically manifests as endocarditis and, if left untreated, is fatal.
  • Current diagnostic methods of Q fever endocarditis are subjective and nonspecific, limiting usefulness in patient diagnostics.
  • Mayo Medical Laboratories has developed a real-time PCR test that permits rapid identification of Coxiella burnetii in infected tissue, blood, or serum.
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  • Real-Time Polymerase Chain Reaction (PCR)
    (PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

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  • Day(s) and Time(s) Test Performed: Monday, Wednesday, Friday; 8 am
  • Test reported Monday through Friday 8 a.m.-5 p.m.
  • Analytic Time: 2 days
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Andy Tofilon

Andy Tofilon is a Marketing Segment Manager at Mayo Medical Laboratories. He leads strategies for corporate communications, public relations, and new media innovations. Andy has worked at Mayo Clinic since 2003. Outside of work, Andy can be found running, hiking, snapping photos, and most importantly, spending time with his family.