In the November issue of Clinical Biochemistry, Mayo Clinic researchers, first author Leslie Donato, Ph.D., conducted a study to assess the performance of two point of care (POC) devices for capillary lipid screening in fasting and post-prandial adults.
During the study, fasting and post-prandial capillary whole blood samples collected from 57 adult donors were analyzed simultaneously on Cholestech LDX Lipid Profile cassettes and CardioChek Lipid Panel strips. Additionally, paired serum samples were collected from the same donors and analyzed with CDC-certified methods for total cholesterol, high density lipoprotein cholesterol (HDL-C) and non-blanked triglycerides. Non-HDL-C (total cholesterol minus HDL-C) and low density lipoprotein cholesterol (LDL-C) were calculated. Mean bias between capillary whole blood and serum laboratory lipids was calculated.
According to the findings, the optimal approach to capillary lipid screening may be to use Cholestech non-HDL cholesterol, as it exhibited little bias relative to CDC reference methods in both fasting and postprandial samples, facilitating lipid screening in non-fasting adults.
Read the full study for more information.
*Additional Mayo Clinic authors include Gayle Deobald, Amy Wockenfus, J. Homseth, A. Saenger, and Brad Karon, M.D., Ph.D.