PathWays Case Study: June 30


pathways063015-2A 70-year-old man presented with a purplish plaque on his cheek. A skin biopsy revealed a diffuse dermal infiltration of medium-sized atypical cells with fine chromatin and scant cytoplasm. The atypical cells were positive for CD4, CD56, CD123, and TCL-1 (Figure 1). Histopathologic findings were consistent with a diagnosis of blastic plasmacytoid dendritic cell neoplasm. One year later, the patient developed pancytopenia, and a bone marrow biopsy revealed an interstitial infiltration by blastic plasmacytoid dendritic cells (Figure 2).

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Siavash Toosi, M.D.

Siavash Toosi, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic





Rebecca L. King, M.D.

Rebecca King, M.D.
Senior Associate Consultant, Division of Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine


April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.



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