Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Activity, Serum [A Test in Focus]


 
The new Lipoprotein-Associated Phospholipase A2 Activity, Serum, test is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. This test should be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of coronary heart disease events.

 

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  • Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory protein produced in the vascular intima. Patients with greater atherosclerotic plaque burden have higher Lp-PLA2 activity.
  • Lp-PLA2 activity is an independent predictor of coronary heart disease events and stroke.
  • This test is for lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and should not be confused with Lp-PLA2 mass assay.
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How to Use This Test

  • This test should be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of coronary heart disease events.
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  • Assays for Lp-PLA2 activity and Lp-PLA2 mass have demonstrated utility in identifying at-risk patients. The activity assay is preferred because the mass assay suffers from significant preanalytical variability.
  • In a population-based study using the REGARDS cohort, individuals with Lp-PLA2 activity levels ≥ 225 nmol/min/mL were at increased risk of coronary heart disease events..
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  •  Enzymatic Colorimetric
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  • Serum
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Day(s) and Time(s) Test Performed:

  • Monday through Saturday; Continuously

Analytic Time:

  • Same day / 1 day
brentwestra

Brent Westra

Brent Westra is a Marketing Segment Manager at Mayo Medical Laboratories. He leads marketing strategies for product management and specialty testing along with new media innovations. Brent has worked at Mayo Clinic since 2011.