PathWays Case Study: August 18



081815--3081815--4081815-1A 13 day-old girl presented with a solitary, congenital, firm, violaceous 3 cm x 3 cm skin mass  of the right lower leg. She was otherwise in good health. Her complete blood count (CBC) and coagulation studies, including PT and PTT, were all in normal range. A diagnostic biopsy was performed, which showed the tumor to consist of multiple dermal nodules of spindled and round cells, in areas forming capillary-sized and "slit-like" vascular channels. The tumor nodules were in part surrounded by hyalinized collagen. The neoplastic cells were small and relatively uniform but slightly hyperchromatic. Mitotic activity was very low and necrosis was absent. Focally the neoplastic cells formed small "glomeruloid" structures, within which could be seen minute platelet aggregates.

The neoplastic cells were CD31, CD34, and FLI1 positive but negative for GLUT1 and HHV-8.

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Ramin Zargham, M.D., Ph.D.

Ramin Zargham, M.D., Ph.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic




Andrew Folpe, M.D.

Andrew Folpe, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine





April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.


Typical case,

Thank you for sharing. Nice case description. Concise and clear.
Very helpful.

A very thorough investigation.

Thank you

Nice case guide rare here and thanks for sharing.

Thank you for sharing. Very helpful

Noce case .Very helpful .Thank you

very well presented case study that involves lots of thoughts and efforts, thanks for sharing.

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