PathWays Case Study: October 20



A 57-year-old woman with a history of acute myeloid leukemia presented with lower extremity edema and weight gain one year following hematopoietic stem cell transplantation (HCT). Her laboratory findings indicate normal renal function, hypoalbuminemia, and a 24-hour urine protein of 1271 mg (normal limits = <167 mg/ 24 hour). Serological studies for complements, antineutrophil antibody (ANA), and antineutrophil cytoplasmic antibody (ANCA) were unremarkable. The serum protein electropheresis (SPEP) and urine protein electropheresis (UPEP) are negative for para-proteins.

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Osamah (Sam) AL Badrim M.B., Ch.B.

Osamah (Sam) AL-Badri, M.B., Ch.B.
Resident, Anatomic Pathology
Mayo Clinic




Mariam (Priya) Alexander, M.D.

Mariam (Priya) Alexander, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine


April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.


Very nice case !

Membranous nephropathy is the most commonly reported glomerular lesion in HCT


thanks for this case

Awesome! Loved this case.

Excellent case! What is the immunofluorescence stain shown?

Another excellent case with very useful discussion Thanks

Very interesting case. And beautiful immunofluoresence photos!!!

Very nice case. I would appreciate it more if you add the IF and HE images of the cases in DD. Thanks again

ANA stand for antinuclear antibody! beware of acronyms.

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