PathWays Case Study: December 8

A 25-year-old male presented to a local emergency department after a serious fall.  Initial laboratory studies revealed pancytopenia. Patient was referred for a bone marrow aspirate and biopsy (bone marrow aspirate is shown in images 1–3 ).





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Michael Keeney, M.D.
Resident, Anatomic/Clinical Pathology
Mayo Clinic




Curtis Hanson, M.D.
Consultant, Division of Hematopathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine


April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.


Great cases! Thank you and keep them coming!

I m frm india…my son pass through sergery….liver tranplant…tyrosinimia type 1
Plz suggest me abt ferther treatment

Hi Manish, unfortunately, we cannot diagnose conditions, provide second opinions or make specific treatment recommendations through this correspondence. If you would like to seek help from Mayo Clinic, please call one of our appointment offices (Arizona: 800-446-2279 Florida: 904-953-0853 Minnesota: 507-538-3270). Thank you.

The question initially looks for a diagnosis of the morphology slides until the figures of chromosomal abnormalities. Fantastic way of presenting such a question.

Thanks! It is quite appetizing for more hematopath. questions!

Great discussion. Highlights the importance of cytogenetic studies in hematologic malignancies. Had to really rack my brains for this one.Thanks !

Good case!
Looking at the picture, Is there a ring chromosome?

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