Algorithmic Approaches to Coagulation Testing: What a Hematologist Should Know

SYMPOSIUM DESCRIPTION

This program is a Friday Satellite Symposium preceding the 57th ASH Annual Meeting. It's overall objective is to inform participants about cost-effective, diagnostically efficient test ordering strategies for evaluation of prolonged screening clotting time tests (PT, APTT), screening and esoteric testing for the patient with bleeding symptoms, lupus anticoagulant testing, laboratory evaluation of thrombophilia and thrombotic microangiopathy, and pediatric coagulation testing. Using test ordering algorithms based on data derived from the Mayo Clinic Special Coagulation Laboratory practice and the literature, we will illustrate how costly and unnecessary biochemical, phenotypic and genetic testing can be avoided for the participants’ practices while enhancing highest quality medical care.


PRESENTATIONS

December 4, 2015

 

TIME PRESENTATION PRESENTER
7-7:30 a.m. Pre-conference Check In / Registration Hyatt Regency Orlando, Regency Room Q  
7:30-7:35 a.m. Introduction  
7:35-8:05 a.m. Prolonged APTT and PT (view slides)

William L. Nichols, M.D.
8:05-8:30 a.m. Evaluation of the Bleeding Patient: Screening Tests (view slides)
Rong He, M.D.
8:30-8:55 a.m. Evaluation of the Bleeding Patient: Esoteric Tests (view slides)

Dong Chen, M.D.
8:55-9:25 a.m. Lupus Anticoagulant and Antiphospholipid Antibodies: Testing Guidelines (view slides)
William L. Nichols, M.D.
9:25-9:40 a.m. Refreshment Break
9:40-10:05 a.m. Algorithmic Thrombophilia Testing (view slides)
Rajiv K. Pruthi, M.B.B.S.
10:05-10:35 a.m. Rational Approach to Evaluation of Thrombotic Microangiopathy (view slides)
C. Christopher Hook , M.D.
10:35-11:00 a.m. Challenges in Pediatric Coagulation Testing (view slides)
Deepti Warad, M.B.B.S.

INTENDED AUDIENCE

Designed for those whose practice and interests include malignant and benign hematologic disorders.

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  • Hematologists
  • Pathologists
  • Oncologists
  • Nurse Practitioners
  • Physician Assistants
  • Nurses
  • Laboratory Scientists

CONFERENCE OBJECTIVES

Upon completion of this activity, participants should be able to:

  • Recount pathophysiologic categories of plasmatic coagulopathies causing prolonged APTT and/or PT.
  • Identify effective laboratory testing strategies for evaluating prolonged APTT and/or PT.
  • Efficiently and cost-effectively utilize coagulation screening tests in the evaluation of bleeding patients.
  • Determine when and how to pursue esoteric testing to diagnose unusual congenital and acquired bleeding disorders.
  • Discuss specific testing recommendations for lupus anticoagulant (LA) including screening, mixing and confirmatory and exclusionary coagulation testing for LA.
  • Identify pre-analytical, analytical, and post-analytical variables impacting results and interpretation of LA testing.
  • Summarize the variables affecting results of assays for thrombophilia
  • Apply an algorithmic approach to thrombophilia testing
  • Use an evidence based algorithm to discriminate between, and correctly diagnose, disorders aggregately described as thrombotic microangiopathies, enabling the selection of appropriate treatment programs.
  • Identify age-related differences in coagulation parameters and recognize the variation of normal ranges with laboratory techniques to aid accurate interpretation.

CREDIT

Mayo Clinic College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Mayo Clinic College of Medicine designates this live activity for a maximum of 3.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


CONFERENCE FACULTY

William L. Nichols, M.D.

  • Co-Course Director
  • Consultant, Divisions of Hematology and Hematopathology
  • Associate Professor of Medicine and Laboratory Medicine
  • Mayo Clinic College of Medicine
  • Mayo Clinic, Rochester, Minnesota

Rajiv K. Pruthi, M.B.B.S.

  • Co-Course Director
  • Consultant, Divisions of Hematology
    and Hematopathology
  • Associate Professor of Medicine
  • Mayo Clinic College of Medicine
  • Mayo Clinic, Rochester, Minnesota

Dong Chen, M.D., Ph.D.

  • Consultant, Division of Hematopathology
  • Associate Professor of Laboratory Medicine and Pathology
  • Mayo Clinic College of Medicine
  • Mayo Clinic, Rochester, Minnesota
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Rong He, M.D.

  • Consultant, Division of Hematopathology
  • Assistant Professor of Laboratory
    Medicine and Pathology
  • Mayo Clinic College of Medicine
  • Mayo Clinic, Rochester, Minnesota

C. Christopher Hook, M.D.

  • Consultant, Division of Hematology and Internal Medicine
  • Associate Professor of Medicine
  • Mayo Clinic College of Medicine
  • Mayo Clinic, Rochester, Minnesota

Deepti M. Warad, M.B.B.S.

  • Senior Associate Consultant, Divisions of Pediatric Hematology/Oncology and Hematopathology
  • Instructor in Pediatrics
  • Mayo Clinic College of Medicine
  • Mayo Clinic, Rochester, Minnesota

FACULTY DISCLOSURE

As a provider accredited by ACCME, Mayo Clinic College of Medicine (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity, and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentation.

National Physician Payment Transparency Program Mayo Clinic College of Medicine complies with the requirements of the National Physician Payment Transparency Program OPEN PAYMENTS (Physician Payments Sunshine Act).