Mayo Clinic Laboratory and Pathology Research Roundup: Feb. 8

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.


Featured Study of the Week

Next-Generation Sequencing: Targeted Panels Versus Whole Exome Sequencing

newtest-ngs-featureNext-generation sequencing is moving beyond targeted panels to whole exome sequencing and even to whole genome sequencing. In a recent article in CAP TODAY,  D. Brian Dawson, Ph.D., co-director of Mayo Clinic's molecular genetics laboratory and an associate professor of laboratory medicine and pathology and medical genetics, discusses Mayo Clinic's use of targeted panels and whole exome sequencing.


Featured Abstracts

Large B-Cell Transformation in Nodular Lymphocyte Predominant Hodgkin Lymphoma: Forty-Year Experience From a Single Institution

Lavender Cap Tube with Eight Possible UsesA number of reports have shown a propensity of nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL) to transform to diffuse large B-cell lymphoma (DLBCL). However, long-term data on the incidence and outcomes of transformed NLPHL is lacking. Mayo Clinic researchers performed a comprehensive, 40-year analysis of its actively maintained Lymphoma Database to assess incidence, outcomes, risk factors, and long-term follow-up of transformation of NLPHL to DLBCL. Based on the results, the risk of transformation was lower than that observed in other low grade lymphomas. The analysis was published in the Blood journal.


Published to PubMed This Week

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Kelley Schreiber

Kelley Schreiber is a Marketing Channel Manager at Mayo Medical Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her new kitten, and exploring new foods.