Novel Anticoagulants: Role of Laboratory Monitoring and its Impact on Coagulation-Based Testing and Lupus Anticoagulant: New CLSI Guidelines for Laboratory Testing

Expires March 1, 2018


Length: 63 minutes


These two presentations were originally delivered during the Mayo Medical Laboratories 2015 Clinical Update in Thrombosis and Anticoagulation Conference. In the first of these videos, Rajiv Pruthi, M.B.B.S., discusses when to monitor novel anticoagulants, the effects of new drugs on laboratory tests, and the availability of assays to monitor novel anticoagulants. In his second presentation, Dr. Pruthi goes on to present recent changes to lupus anticoagulation diagnostic guidelines and antiphospholipid antibody testing.


At the completion of this activity, participants should be able to:

  • Explain the effects of novel anticoagulants on commonly ordered coagulation assays.
  • Recognize the circumstances in which monitoring may be useful.
  • Summarize limitations of currently available assays.
  • Review availability of assays to monitor novel anticoagulants.
  • Discuss the criteria and recommendations for lupus anticoagulation syndrome.
  • Recognize antiphospholipid antibodies.
  • Explain why in vitro findings (prolonged clotting times) differ from in vivo events (thrombosis).

Intended Audience

This program is appropriate for clinicians, pathologists, medical technologists, nurses, pharmacists, and other allied health staff.

Level of Instruction



Photo of Rajiv Pruthi, M.B.B.S.Rajiv Pruthi, M.B.B.S.
Department of Hematology
Department of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, Minnesota



The following types of credit are offered for our Virtual Lecture programs:

State of California
State of Florida

To obtain credit:

  1. Watch the video.
  2. Complete the posttest and evaluation that launches immediately following the video.
  3. Generate and print your certificate.

For an instruction sheet that describes the process, see

Note: Participants requesting P.A.C.E.© credit, in compliance with ASCLS P.A.C.E. program requirements, must attain a score of 70% or higher on the posttest to obtain a certificate.

Mayo Medical Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for a maximum of 1.0 P.A.C.E® contact hours. Level of instruction for this program is intermediate.

Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Science for State of California and State of Florida credit. Florida Board of Clinical Laboratory Personnel has designated this program for General (Hematology) credit. The level of instruction for this program is intermediate. This program has been approved for 1.0 contact hour.


MML Education

This post was developed by our Education and Technical Publications Team.