2016 United States and Canadian Academy of Pathology (USCAP) Annual Meeting

Physicians, scientists, genetic counselors, and allied health staff from Mayo Clinic and Mayo Medical Laboratories are currently attending the United States and Canadian Academy of Pathology (USCAP) 2016 Annual Meeting in Seattle.

In addition to attending, our staff will also be represented by numerous presentations and abstracts, Mayo Clinic Consultants will be available at our booth (#624) Monday, March 14th, from 4-5 pm to answer questions.

Mayo Medical Laboratories representatives will also be available during all exhibit hall hours to discuss:

  • NGS TESTING: Clinically actionable panels to identify mutations across
    numerous genes
  • ONCOLOGY TESTING: Clinically Actionable Testing and Consultation to Guide Patient Care and Manage Treatment Costs
  • HEMATOLOGY TESTING: Advancing the Diagnosis of Hematologic Disorders
  • MAYO CLINIC WORKING GROUPS: Integrated, Multidisciplinary Teams of Pathologists, Clinical Laboratorians, and Physician Specialists to Guide Patient Care
  • MAYO CLINIC PRESENTATIONS: Special Courses, Short Courses, Poster Presentations, and Proffered Paper Presentations


NGS TESTING

Next generation sequencing has emerged as an accurate, cost-effective method to identify mutations across numerous genes known to be associated with response or resistance to specific targeted therapies.

Resources:


ONCOLOGY TESTING

Mayo Clinic is the most robust laboratory and pathology practice for cancer care in the world. We offer testing that spans diagnostic, theranostic, and prognostic approaches with accompanying specialists for every type and stage of cancer.

Resources:


HEMATOLOGY TESTING

As hematology and hematopathology has become an increasingly complex subspecialty, particularly with neoplastic disorders of blood and bone marrow, providing diagnostic, prognostic, and treatment information now requires going beyond the standard test offerings of other laboratories. Our comprehensive test menu has been created to diagnose and treat the full spectrum of hematologic disorders.

Resources:


MAYO CLINIC CONSULTANT WORKING GROUPS

A large number of our cases are reviewed by more than one subspecialist pathologist to ensure the best interpretation. This close relationship among Mayo Clinic’s pathologists, clinical laboratorians, and oncologists creates clinical and research collaboration and generates the unique ability to successfully integrate stateof-the-art scientific achievements into clinical practice for patients.

This collaboration also ensures that the right tests are developed, validated, and implemented for the clinical practice and that these tests are ordered at the right time and in the right clinical scenario to help guide patient care.

When a difficult case poses several differential diagnoses, access to the expertise of Mayo Clinic’s consultant working groups creates, in essence, an ad hoc consensus conference or tumor board to form the best opinion.

Consultant Working Groups:

Bone & Soft Tissue Breast Cytopathology
Endocrine Eye Gastrointestinal
Genitourinary Gynecological Head & Neck
Lung Lymph Node Neuro-oncology
Skin    


MAYO CLINIC PRESENTATIONS AT USCAP

EVENING SPECIALTY CONFERENCE

March 16 | 7:30 to 9:30 p.m.
Current Controversies in Hematopathology – Case #2
Andrew Feldman, M.D.


SPECIAL COURSE

March 15, 2016 | 1:50 p.m.
Colorectal Cancer: Molecular Testing for the Surgical Pathologist
Special Course: Molecular Diagnostic and Genomic Applications in Cancer: A Primer for the Pathologist
Kevin Halling, M.D., Ph.D.


SHORT COURSES

March 16 | 8:00 a.m. - 12:00 p.m.

SC05: The Nerve Of Some Nerve Sheath Tumors! A Practical Approach To Common Problems In Surgical Pathology
Caterina Giannini, M.D.

SC11: Contemporary Cardiovascular Pathology from Bench to Bedside: How Emerging Ancillary Tools are Transforming the Field
Joseph J. Maleszewski, MD

SC22: Practical Guide to Error Reduction, Effective Communication, and Damage Control in Surgical Pathology
Raouf Nakhleh, MD

SC55:A Practical Approach to Infectious Disease Pathology
Bobbi S. Pritt, MD, MS

March 16 | 1:30 - 5:30 p.m.
SC43: Medical Liver Biopsies: Translating Morphologic Patterns Into Meaningful Pathology Reports
Michael Torbenson, MD

SC59: Occupationally Related Pleural and Pulmonary Disorders in the 21st Century: Challenges, Pitfalls and No-Nos
Henry D. Tazelaar MD

March 17 | 1:00 - 4:30 p.m.
SC14: Biopsies of Mediastinal Lesions: Challenges, Pitfalls and Practical Tips
Anja C. Roden, MD; Jennifer M. Boland, MD, and Marie Christine Aubry, MD

March 18 | 8:00 - 11:30 a.m.
SC09: Recent Developments in Heart and Lung Transplant Pathology: Navigating the Shifting Sands
Henry D. Tazelaar, MD

March 18 | 1:00 - 4:30 p.m.
SC38: Common Diagnostic Dilemmas in Head and Neck Pathology: Pitfalls, Pearls and Clinical Insights
Qihui Jim Zhai, MD, and John Casler, MD


PROFFERED PAPERS AND POSTER PRESENTATIONS

MONDAY, MARCH 14

Title: Microglandular Adenosis and Risk of Breast Cancer: A Mayo Benign Breast Disease Cohort Study
Publication Number: [119]
Authors: Melanie C Bois, Zahraa Al-Hilli, Daniel W Visscher, Tanya L Hoskin, Marlene H Frost, Derek C Radisky, Ruth Kraft, Amy Degnim, Jodi M Carter

Title: Evaluation For Heritable Cardiovascular Disorders Using Targeted Next-Generation Sequencing on Formalin-Fixed Paraffin Embedded Tissue
Publication Number: [324]
Authors: Charles Leduc, Laura J Train, Rajeswari Avula, Katrina E Kotzer, Michelle L Kluge, Michael J Ackerman, Linnea M Baudhuin, Joseph J Maleszewski

Title: Regional Differences in Ascending Aortic Histology: A Comparative Histomorphologic Assessment with Implication for Pathologic Classification
Publication Number: [314]
Authors: Md Shahrier Amin, Cecilia Wu, Charles Leduc, Peter T Lin, Sarah M Jenkins, William D Edwards, Joseph J Maleszewski

Title: Most High Grade Serous Carcinomas Arising in Low Grade Serous Carcinomas Do Not Show Evidence of TP53 or BRAF Mutations
Publication Number: [1254]
Authors: Shabnam Zarei, Sarah E Kerr, Yan Wang, Sarah M Jenkins, Debra A Bell

Title: Primary Mediastinal Germ Cell Tumors: A Clinicopathologic Study of 32 Cases
Publication Number: [1884]
Authors: Liping Liu, Rafael E Jimenez, John C Cheville, Marie-Christine Aubry, Anja C Roden

Title: Pleuropulmonary Solitary Fibrous Tumors- A Clinicopathologic Study of 84 Cases with Comparison of Proposed Risk Stratification Systems
Publication Number: [1893]
Authors: Wadad Mneimneh, Sarah M Jenkins, Marie Christine Aubry, Jennifer M Boland

Title: Impact of Atypia within Multiple Non-Synchronous Biopsies on Breast Cancer Risk: A Mayo Benign Breast Disease Cohort Study
Publication Number: [133]
Authors: Jodi M Carter, Ryan D Frank, Robert A Vierkant, Stacey Winham, Derek C Radisky, Marlene H Frost, Ruth Kraft, Amy Degnim, Daniel Visscher

Title: Clinical-Pathological Analysis of Women with Proliferative Breast Disease Undergoing Multiple Benign Biopsies: A Mayo Benign Breast Disease Cohort Study
Publication Number: [132]
Authors: Jodi M Carter, Derek C Radisky, Ryan D Frank, Robert A Vierkant, Stacey Winham, Marlene H Frost, Amy Degnim, Daniel W Visscher

Title: Risk of Breast Cancer among African American Women with Sclerosing Adenosis and Radial Scar
Publication Number: [251]
Authors: Vishakha Pardeshi, Michele L Cote, Julie J Ruterbusch, Eman Abdulfatah, Woodlyne Roquiz, Baraa Alosh, Muhammad K Alsafadi, Daniel W Visscher, Sudeshna Bandyopadhyay, Rouba Ali-Fehmi

Title: Adenosquamous Carcinoma and Adenosquamous Intraepithelial Lesion of the Cervix: Analysis of a Rigorously Classified Case Series
Publication Number: [1156]
Authors: Michael Keeney, Gary L Keeney, John Schoolmeester

Title: Role of CRTC1/MAML2 Translocation in Determining Prognosis and Clinical Outcomes in Mucoepidermoid Carcinoma Patients: The MD Anderson Experience
Publication Number: [1266]
Authors: Diana Bell, Rami E Saade, Joaquin J Garcia, Dianna Roberts, Randal S Weber

Title: Pulmonary Mucinous Adenocarcinoma- A Molecular Genetic Study of 52 Cases
Publication Number: [1855]
Authors: Jennifer M Boland, Joseph J Maleszewski, Benjamin R Kipp, Jason A Wampfler, Ping Yang, Eunhee S Yi

Title: Correlation of Histologic and Radiologic Response to Neoadjuvant Treatment of Thymic Epithelial Tumors
Publication Number: [1911]
Authors: Anja C Roden, Marie Christine Aubry, Eunhee S Yi, Sarah M Jenkins, Yolanda I Garces, Randolph S Marks, Stephen D Cassivi, Geoffrey B Johnson

Title: Utilization of Pathologists' Assistants in the Diagnostic Arena: Working Differently in the Changing Health Care Environment
Publication Number: [1951]
Authors: Melissa M Blessing, David Schembri Wismayer, Diva R Salomao, Adam J Wood, Sarah E Kerr, Monica L Kendall, Kenneth M Smith, Carrie Y Inwards, Gary L Keeney, Mariam P AlexanderSession Information: Poster Session II #277, Monday Afternoon

Title: Prospective Quality Assurance of Breast Core Biopsies Minimizes Errors and Improves Patient Safety
Publication Number: [2005]
Authors: Sejal S Shah, Natalie S Campbell, Gary L Keeney, Beiyun Chen, Daniel W Visscher

TUESDAY, MARCH 15

Title: Spindle Cell Lipoma Arising at Atypical Locations: A Clinicopathologic Review of 56 Cases
Publication Number: [100]
Authors: Pingchuan Zhang, Nasir Ud Din, Andrew L Folpe, Karen Fritchie

Title: Apolipoprotein A-IV Associated Cardiac Amyloidosis
Publication Number: [319]
Authors: Melanie C Bois, Surendra Dasari, Jason D Theis, Julie Vrana, Martha Grogan, Angela Dispenzieri, Paul J Kurtin, Joseph J Maleszewski

Title: Cardiac Angiosarcoma: Histopathologic, Immunohistochemical, and Molecular Genetic Analysis of 10 Cases
Publication Number: [325]
Authors: Charles Leduc, William R Sukov, Jeannette G Rustin, Joseph J Maleszewski

Title: Sporadic Gastric Well-Differentiated Neuroendocrine Tumors Have a Higher Ki-67 Proliferation Index
Publication Number: [714]
Authors: Hee Eun Lee, Taofic Mounajjed, Lori A Erickson, Tsung-Teh Wu

Title: Paraganglioma Associated Renal Lesions
Publication Number: [937]
Authors: Sounak Gupta, Jun Zhang, Lori A Erickson

Title: Hepar-1 Loss in Telangiectatic/Inflammatory Hepatic Adenomas - A Novel Observation with Potential Tumor Biology Implications
Publication Number: [1665]
Authors: Andrea Jones, Rondell Graham, Taofic Mounajjed, Michael Torbenson, Roger Moreira

Title: Copper Deposition in Focal Nodular Hyperplasia and Inflammatory Hepatic Adenoma
Publication Number: [1645]
Authors: Vishal Chandan, Taofic Mounajjed, Sejal S Shah, Michael Torbenson, Tsung-Teh Wu

Title: Atypical Teratoid/Rhabdoid Tumors (AT/RTs) of the Sellar Region in Adults: Characterization of Five Cases
Publication Number: [1724]
Authors: Michael Paolini, Benjamin R Kipp, William R Sukov, Aditya Raghunathan, Emily G Barr Fritcher, Derick M Aranda, Karen SantaCruz, Sadeq Al-Dandan, Pete Fisher, William McDonald, Charles P Bondurant, Grant Van Dyke Darkow, Caterina Giannini, Joseph E Parisi, Mark E Jentoft

Title: Loss of p16INK4A Expression Predicts Worse Outcome in Thymic Carcinoma
Publication Number: [1849]
Authors: Scott W Aesif, Marie-Christine Aubry, Eunhee S Yi, Sarah M Jenkins, Grant Spears, Anja C Roden

Title: TFE3 Immunohistochemistry: A Comparison of Two Methods, with Discussion of the Implications for the Diagnosis of TFE3-Rearranged Neoplasms
Publication Number: [2069]
Authors: Rosalind Sandell, Allen M Gown, Andrew L Folpe

Title: Cytologic Characteristics of Resistant Locally Advanced Breast Carcinoma after Neoadjuvant Treatment
Publication Number: [230]
Authors: Ann M Moyer, Daniel W Visscher, Vera J Suman, Travis J Dockter, Krishna R Kalari, Donald W Northfelt, Sarah A McLaughlin, Alvaro Moreno-Aspitia, Richard J Gray, Judy C Boughey, Matthew Goetz

Title: Expression of Activated B-Cell Factor-1 in ALK-Negative Anaplastic Large Cell and Other Lymphomas
Publication Number: [1363]
Authors: Andrew L Feldman, Yu Zeng, Rebecca L Boddicker, Michael Zimmermann, Karen L Grogg, James R Cerhan, Susan L Slager, Matthew Maurer, Cristine Allmer, Thomas Habermann, Brian Link, Surendra Dasari

Title: The Role of Communication between Physician, Pathologist and Family in Autopsy Rate
Publication Number: [15]
Authors: Justin Juskewitch, Michael Paolini, Joseph J Maleszewski, R Ross Reichard, Marie-Christine Aubry

Title: Molecularly Defined Adult Gliomas with Known ATRX Status: Does TERT Have an Additional Prognostic Role
Publication Number: [1725]
Authors: Melike Pekmezci, Kyle M Walsh, Annette Molinaro, Paul A Decker, Helen M Hansen, Hugues Sicotto, Terri Rice, Tom Kollmeyer, Lucie McCoy, Gobinda Sarkar, Alissa A Caron, Arie Perry, Caterina Giannini, Tarik Tihan, Mitchel S Berger, Joseph Wiemels, Jeanette Eckel-Passow, Dan Lachance, John Wiencke, Robert B Jenkins, Margaret Wrensch

Title: Fibrous Hamartoma of Infancy- A Clinicopathologic Study of 122 Cases, Including 2 with Malignant Progression
Publication Number: [36]
Authors: Alyaa Al-Ibraheemi, Anthony Martinez, Sharon W Weiss, Harry Kozakewich, Antonio Perez-Atayde, Karen Fritchie, Andrew L Folpe

Title: Malignant Tenosynovial Giant Cell Tumor- A Clinicopathological and Immunohistochemical Study of 7 Cases
Publication Number: [37]
Authors: Alyaa Al-Ibraheemi, Andre Oliveira, Andrew L Folpe

Title: Clinical-Pathologic Analysis of Luminal B Breast Carcinoma
Publication Number: [305]
Authors: Xuemei Wu, Judy C Boughey, Ann M Moyer, Krishna R Kalari, Vera J Suman, Jason P Sinnwell, Erin E Carlson, Travis J Dockter, Alvaro Moreno-Aspitia, Richard J Gray, Sarah A McLaughlin, Donald W Northfelt, Katie N Jones, Amy L Conners, Eric D Wieben, Liewei Wang, Richard M Weinshilboum, Matthew Goetz, Daniel W Visscher

Title: ALK-1 Expression in Metastatic Melanoma: Potential for a Therapeutic Target
Publication Number: [529]
Authors: Kabeer Shah, Justin Moser, Aaron S Mansfield, Lori A Erickson, Thomas Flotte

Title: Prognostic Significance of Lymphatic, Vascular and Perineural Invasion in Bladder Cancer Treated by Radical Cystectomy
Publication Number: [999]
Authors: Prasuna Muppa, Sounak Gupta, Igor Frank, Stephen A Boorjian, R Jeffrey Karnes, R Houston Thompson, Prabin Thapa, Robert F Tarrell, Loren P Herrera Hernandez, Rafael E Jimenez, John C Cheville

Title: Urinary Bladder Paragangliomas: Analysis of Succinate Dehydrogenase and Outcome
Publication Number: [936]
Authors: Sounak Gupta, Jun Zhang, Lori A Erickson

Title: Arrested Pneumatization of the Skull Base: A Sheep in Wolf's Clothing
Publication Number: [1290]
Authors: Jean Lewis, Carrie Y Inwards, Kirk M Welker

Title: The Expanded Eight-Probe Melanoma Fluorescence In Situ Hybridization (FISH) Assay as an Ancillary Tool in Diagnosing Ambiguous Melanocytic Lesions: An Updated Clinical, Pathological and Cytogenetic Review of 416 Cases
Publication Number: [500]
Authors: Ruifeng Guo, Kabeer Shah, Lori A Erickson, Thomas Flotte, William R Sukov

Title: Nuclear TFE3 Immunoreactivity Is Present in Angiomatoid Fibrous Histiocytomas but Not in Other Cutaneous Histiocytomas
Publication Number: [536]
Authors: Dianne Torrence, Karen Fritchie, John D Reith, William R Sukov, Wonwoo Shon

Title: Quantitation of Oil Red O Staining Via Digital Imaging Analysis in the Evaluation for Pulmonary Fat Embolization at Autopsy
Publication Number: [4]
Authors: Melissa M Blessing, Toby C Cornish, John R Lehman, Sarah M Jenkins, Joseph J Maleszewski, Marie Christine Aubry, Peter T Lin

WEDNESDAY, MARCH 16

Title: Luminal Androgen Receptor (LAR) Subtype Breast Cancers Are Not Histologically Defined by Apocrine Morphology
Publication Number: [229]
Authors: Ann M Moyer, Xuemei Wu, Daniel W Visscher, Krishna R Kalari, Kevin J Thompson, Xiaojia Tang, Vera J Suman, Travis J Dockter, Sarah A McLaughlin, Alvaro Moreno-Aspitia, Donald W Northfelt, Richard J Gray, Katie N Jones, Amy L Conners, Eric D Wieben, Liewei Wang, Richard M Weinshilboum, Matthew Goetz, Judy C Boughey

Title: Hyaline Fibrous Involution: A Novel Histologic Finding That Is More Common in BRCA+ Breast Tissue
Publication Number: [204]
Authors: Hee Eun Lee, Muhammad Arshad, Rushin D Brahmbhat, Tanya L Hoskin, Stacey Winham, Marlene H Frost, Derek C Radisky, Lori Denison, Amy Degnim, Daniel W Visscher

Title: GATA3 Expression in Malignant Mesothelioma Is a Potential Pitfall in Effusion Cytology
Publication Number: [446]
Authors: Jennifer L Sauter, Sarah E Kerr

Title: Retrospective Review of Colectomy in Patients with Pre-Pouch Ieitis after Surgery for Ulcerative Colitis
Publication Number: [745]
Authors: Prasuna Muppa, Saba Yasir, Laura E Raffals, Thomas C Smyrk

Title: Pathology Review for ECOG 1412: A Comparison of NanoString Gene Expression Profiling and Immunohistochemistry for Cell-of-Origin Testing in De-Novo Diffuse Large B-Cell Lymphoma
Publication Number: [1408]
Authors: Rebecca King, David W Scott, Randy D Gascoyne, Marissa A Fitzgibbons, Grzegorz S Nowakowski, Thomas E Witzig, William R Maco

Title: Programmed Death Ligand-1 Expression on Tumor Cells in Cholangiocarcinoma Is More Frequent in Poorly Differentiated and Intrahepatic Tumors and Tumors with Brisk Tumor Infiltrating Lymphocytes
Publication Number: [1685]
Authors: Michael Torbenson, Taofic Mounajjed, Benjamin R Kipp, Robert R McWilliams, Rondell Graham

Title: Histopathologic Findings in the Lungs of Patients Treated with Extracorporeal Membrane Oxygenation
Publication Number: [1881]
Authors: Hee Eun Lee, Eunhee S Yi, Anja C Roden

Title: Optimization of Tissue Section Thickness for Evaluation of Mitotic Figures in Whole Slide Imaging (WSI)
Publication Number: [2093]
Authors: Shabnam Zarei, Xuemei Wu, Sarah M Jenkins, William Flotte, Taofic Mounajjed, Thomas Flotte

Title: Pediatric Non-Vestibular Schwannomas: A Clinicopathologic Study of 22 Patients
Publication Number: [42]
Authors: Cory Broehm, Karen Fritchie

Title: Anastomosing Hemangiomas Arising in Unusual Locations: A Clinicopathological Study of 15 Cases Showing a Predilection for the Paraspinal Region
Publication Number: [63]
Authors: Ivy John, Andrew L Folpe

Title: Histologic Spectrum of Giant Cell Tumor (GCT) of Bone in Patients < 18 Years of Age: A Study of 66 Patients
Publication Number: [35]
Authors: Alyaa Al-Ibraheemi, Jodi M Carter, Riyam T Zreik, Carrie Y Inwards, Karen Fritchie

Title: Extraosseous, Extradural Chordomas of the Spine: A Unique Chordoma Subset
Publication Number: [43]
Authors: Jodi M Carter, Doris E Wenger, Carrie Y Inwards

Title: Utility of a Pan Genomic Fusion Panel (1300 Genes) on a Next Generation Sequencing (NGS) Platform in Evaluation of Bone and Soft Tissue Sarcoma
Publication Number: [71]
Authors: Ravindra Kolhe, Karen Fritchie, Alka Chaubey, Lisa C Watson, Claire Attwooll, WonSok Lee, Deepa Jagdale, Ashis K Mondal

Title: Mass Spectrometry-Based Proteomics Identifies Lactotransferrin as Co-Localizing Protein in Amyloidosis of the Breast
Publication Number: [163]
Authors: Karen L Grogg, Julie A Vrana, Bolette Lynn Caron, Jason D Theis, Paul J Kurtin

Title: Comparative Analysis of Neuroendocrine Phenotype in Metastases from Advanced Prostate Cancer and Their Corresponding Primary Tumor
Publication Number: [959]
Authors: Rafael E Jimenez, Jad Abbas, John C Cheville, Manish Kohli

Title: PD-L1 Expression Is Uncommon in Advanced-Staged Endometrial Carcinoma
Publication Number: [1225]
Authors: Jennifer L Sauter, Rondell Graham, Jo Marie Janco, Andrea Mariani, Sarah E Kerr

Title: ECOG 1412: High Rejection Rate for Submitted Diffuse Large B-cell Lymphomas (DLBCLs) upon Retrospective Central Pathology Review (CPR)
Results in Protocol Change to Novel Real-Time CPR to Establish Patient Eligibility
Publication Number: [1426]
Authors: William R Macon, Rebecca King

Title: A Small Series of Bone Marrow Indolent Clonal CD4-Positive T-Cell Lymphoproliferative Disorder: A New Entity?
Publication Number: [1338]
Authors: Aleh Bobr, Dong Chen, William G Morice, Karen L Grogg, Min Shi

Title: Bilineal Large Granular Lymphocytic Leukemia: A Distinct Subtype of LGL?
Publication Number: [1442]
Authors: Jadee L Neff, Dragan Jevremovic, William G Morice, Min Shi

Title: Clonality Analysis of T-Cell Receptor Gamma Rearrangement (TCGR) by Next Generation Sequencing (NGS) in Anaplastic Large Cell Lymphomas (ALCL)
Publication Number: [1386]
Authors: Rong He, Ming Mai, David S Viswanatha, Andrew L Feldman

brentwestra

Brent Westra

Brent Westra is a Marketing Segment Manager at Mayo Medical Laboratories. He leads marketing strategies for product management and specialty testing along with new media innovations. Brent has worked at Mayo Clinic since 2011.