Mayo Clinic Laboratory and Pathology Research Roundup: May 23

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.


Featured Study of the Week

Analytical and Clinical Validation of an LC–MS/MS Method for Urine Leukotriene E4

research-laboratory-test-tubes-and-blue-glove-on-researcher-16x9Systemic mastocytosis is a disorder characterized by the abnormal accumulation of mast cells, which are typically responsible for allergic reactions.Mast cells are trigged by unique antigens, which means that each individual responds in a different way when mast cells are activated in the body. Mayo Clinic researchers hypothesized that urinary Leukotriene E4 could be used alone or in combination with N-methyl histamine and 11-beta prostaglandin F2α to optimize screening for systemic mastocytosis. In a recent study published in Clinical Biochemistry, the researchers describe a novel (LC–MS/MS) assay to accurately and precisely quantitate LTE4 in urine and outline its clinical utility in systemic mastocytosis screening.


Published to PubMed This Week

brentwestra

Brent Westra

Brent Westra is a Marketing Segment Manager at Mayo Medical Laboratories. He leads marketing strategies for product management and specialty testing along with new media innovations. Brent has worked at Mayo Clinic since 2011.