PathWays Case Study for May 24

A 77-year-old man had progressive dyspnea with exertion and slight left anterior chest wall pain. He was later diagnosed with sarcomatoid carcinoma of the mandible and maxilla and treated with resection and adjuvant radiation therapy. Postoperatively, he developed worsening dyspnea and pericardial effusion with evidence of tamponade and died two months later. A pleural lesion was identified at autopsy (figures).


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Xuemei Wu, B.Med., Ph.D.
Resident, Anatomic Pathology Residency
Mayo Clinic






Anja Roden, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine


April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.


This is very interesting case which i learned lot from it. I wish these cases should be reviewed by all Medical students, Pathologist and all the internists.

Nice case. … Invasion can be identified without difficulty in case of autopsy specimens.

In case of limited biopsy tissue ………..
Although reactive mesothelial proliferation are non invasive entrapment of benign mesothelial cells within the fibrous tissue of organising inflammation can simulate neoplastic invasion making histological discrimination between entrapment and invasion difficult . When the invasion cannot be identified it is designated as atypical mesothelial hyperplasia.
But clinical decision making for the diagnosis of malignancy is possible by correlating with serial imaging studies and more adequate biopsy 🙂 ….
Thanks for the valuable information regarding p16 and BAP ….

thank yuo for the valuable information that you delivered for us we appreciate your effort in a teaching the juniors and seniors doctors. The word sume times not enough to express our feeling.
thank yuo

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