A female patient was admitted due to a short history of lower abdominal pain. Emergent exploratory laparotomy revealed a ruptured left ovarian mass. Grossly, the tumor measured 28 cm in greatest dimension with a cystic and solid-cut surface. Immunohistochemical stains were performed, and the tumor cells were strongly positive for chromogranin A, synaptophysin, CK AE1/AE3, and CK20. Representative H&E images are shown here. A diagnosis of ovarian large cell neuroendocrine carcinoma was made.
Xiaotun Zhang, M.B.
Resident, Anatomic Pathology Residency
Debra A. Bell, M.D.
Consultant, Division of Anatomic Pathology
Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine