PathWays Case Study: Aug. 9

A 57-year-old woman was diagnosed with acute promyelocytic leukemia (APL) involving 40% of her bone marrow confirmed by PML-RARA quantitative PCR. She was started on induction therapy but developed treatment-related long QTc syndrome. Her regimen was reduced, and soon after, a follow-up bone marrow biopsy was performed. The bone marrow aspirate showed no morphologic features of residual acute leukemia but did reveal markedly bizarre erythroid atypia not seen in her earlier bone marrow specimen (see images).





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Justin Juskewitch, M.D., Ph.D.

Justin Juskewitch, M.D., Ph.D.
Resident, Division of Anatomic and Clinical Pathology
Mayo Clinic





Min Shi, M.D., Ph.D.

Min Shi, M.D., Ph.D.
Consultant, Division of Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine


April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.


We had case of APL some time ago. This is the reason that I remembered.

I have reviewed the APL case with cytopathology students last grand round CME.
I will share with them this case. I find these cases are very good.


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