PathWays Case Study: Aug. 16

The patient is a 45-year-old man who presented with renal vein thrombosis requiring urgent anti-coagulation. His serum creatinine was 1.1 mg/dL with an albumin of 3.2 g/dL. No monoclonal proteins were detected on serum protein electrophoresis. Cryoglobulins and cryofibrinogens were negative. C3 was elevated at 181 mg/dL and C4 was normal at 29 mg/dL. ANA and Anti-ds DNA were negative. Quantitative urinalysis shows a total protein of 3665 mg/24 hour.

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Immunofluorescence: IgG

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Pingchuan Zhang, B.M.
Resident, Renal Pathology
Mayo Clinic

 

 

 

 

Alexander_Mariam_P_15S

Mariam (Priya) Alexander, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine

apriljosselyn

April Josselyn

April Josselyn is a Marketing Associate at Mayo Medical Laboratories. She is the editor of Mayo Clinic PathWays and supports corporate communications strategies and internal communications. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.

Responses

good.

Got it

the negativity of PLA2R in kidney biopsies is it a directe consequence of the effect of the auto-antibodies fixed on these receptor?

Very nice case and well written explaination!

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