Live updates from Kelley Schreiber, Andy Tofilon, and Brent Westra

Mayo Clinic hematologists, hematopathologists, and a wide spectrum of allied health staff are in San Diego for the 58th American Society of Hematology Annual Meeting & Exhibition. Follow this blog for live updates from #ASH16 as we attend the conference, mingle with colleagues at booth #3613, and have a little fun. Have a comment or photo to share? Send it to us on Twitter (@MayoClinicLabs) or Facebook.


Dec. 5 at 9:00 p.m. PST

That's a Wrap

We had a wonderful time at #ASH16 and in San Diego!

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Dec. 5 at 2:00 p.m. PST

#ASH16 Audio Insights with Juliana Perez Botero, M.D.

On Monday morning, we met Dr. Juliana Perez Botero at our exhibit at #ASH16 to learn more about her Saturday poster presentation and the important intersect between hematology and transfusion medicine. Listen now:


Dec. 5 at 11:00 a.m. PST

#ASH16 Audio Insights with Linda Baughn, Ph.D.

On Day 2 of #ASH16, Dr. Linda Baughn met us in our exhibit to catch up on her impressions and highlights from this year's annual meeting. Listen now:


Dec. 5 at 9:45 a.m. PST

#ASH16 Audio Insights with Aneel Ashrani, M.D.

This year's final symposium speaker was Dr. Aneel Ashrani. We chatted with him after the event to discuss what he was looking forward to this year at ASH and learn more about his presentation, "Malignancy-Associated Coagulopathy: Recognition and Laboratory Diagnosis." Listen now:


Dec. 5 at 8:50 a.m. PST

Oral Presentations: Monday, Dec. 5

Our colleagues from the Mayo Clinic Department of Laboratory Medicine and Pathology will be presenting the following oral presentations today:

Ruxolitinib Prevents Cytokine Release Syndrome after CART Cell Therapy without Impairing the Anti-Tumor Effect in a Xenograft Model

Presenter: Saad Kenderian, M.B., Ch.B.
Time and Location: 7 a.m.–8:30 a.m., Room 6CF (San Diego Convention Center)

NEOD001 Demonstrates Organ Biomarker Responses in Patients with Light Chain Amyloidosis and Persistent Organ Dysfunction: Results from the Expansion Cohort of a Phase 1/2 Study

Presenter: Morie Gertz, M.D.
Time and Location: 7 a.m.–8:30 a.m., Hall AB (San Diego Convention Center)

Estimating the Risk of Progression of Monoclonal Gammopathy of Undetermined Significance into Lymphoplasmacytic Malignancies in the United States: Determining Demographic Differences Using a National Dataset

Presenter: Ronald Go, M.D.
Time and Location: 10:30 a.m.–Noon, Grand Hall B (Manchester Grand Hyatt San Diego)

Leukemia Stem Cells Are Characterized by CLEC12A Expression and Chemotherapy Refractoriness that Can be Overcome by Targeting with Chimeric Antigen Receptor T Cells

Presenter: Saad Kenderian, M.B, Ch.B.
Time and Location: 10:30 a.m.–Noon, San Diego Ballroom AB (Marriott Marquis San Diego Marina)

End-of-Life Discussions in Hematologic Malignancies (Adult Perspective)

Presenter: Mark Litzow, M.D.
Time and Location: 10:30 a.m.–Noon, Marriott Grand 11-13 (Marriott Marquis San Diego Marina)

Integrating Epidemiology into Clinical Trials in AML

Presenter: James Foran, M.D.
Time and Location: 1 p.m.–6 p.m., Room 5AB (San Diego Convention Center)

An International Assessment of Event-Free Survival at 24 Months (EFS24) and Subsequent Survival in Peripheral T-Cell Lymphoma

Presenter: Matthew Maurer
Time and Location: 2:45 p.m.–4:15 p.m., Room 6B (San Diego Convention Center)

A Risk Stratification Model Using Quantification of Circulating Plasma Cells in Multiple Myeloma Prior to Autologous Stem Cell Transplantation in the Era of Novel Agents

Presenter: Rajshekhar Chakraborty, M.B.B.S.
Time and Location: 2:45 p.m.–4:15 p.m., Seaport Ballroom DE (Manchester Grand Hyatt San Diego)

TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome

Presenter: Jie Sun, Ph.D.
Time and Location: 4:30 p.m.–6 p.m., Pacific Ballroom 24-26 (Marriott Marquis San Diego Marina)

Vitamin D Insufficiency Is Associated with an Increased Risk of Early Clinical Failure in Follicular Lymphoma

Presenter: Sean Tracy, M.D., Ph.D.
Time and Location: 4:30 p.m.–6 p.m., Ballroom 20A (San Diego Convention Center)

The Prognostic Significance of Polyclonal Bone Marrow Plasma Cells in Patients with Actively Relapsing Multiple Myeloma

Presenter: Toshi Ghosh, M.D.
Time and Location: 4:30 p.m.–6 p.m., Room 29 (San Diego Convention Center)

Momelotinib Therapy in Myelofibrosis: 6-Years Follow-up Data on Safety, Efficacy, and the Impact of Mutations on Overall and Relapse-Free Survival

Presenter: Ayalew Tefferi, M.D.
Time and Location: 4:30 p.m.–6 p.m., Pacific Ballroom 15-17 (Marriott Marquis San Diego Marina)

Disease and Outcome Disparities in Multiple Myeloma (MM): Exploring the Role of Race/Ethnicity and Obesity in Cooperative Group Clinical Trials

Presenter: Sikander Ailawadhi, M.D.
Time and Location: 4:30 p.m.–6 p.m., Room 29 (San Diego Convention Center)

Psychiatric Comorbidities Are Associated with Increased Cost of Care and Health Care Utilization in Multiple Myeloma Patients

Presenter: Shehzad Niazi, M.D.
Time and Location: 6:15 p.m.–7:45 p.m., Room 28ABCD (San Diego Convention Center)


Dec. 4 at 2:30 p.m. PST

#ASH16 Audio Insights with Ellen McPhail, M.D.

We caught up with Dr. McPhail during #ASH16 to learn what projects she's been involved with during the conference, what she's most excited for at ASH and in San Diego, and why she thinks it's important for professionals to attend the conference. Listen now:


Dec. 4 at 12:20 p.m. PST

Dr. Mesa on Upcoming Updates to NCCN Guideline for MPNs

Ruben Mesa, M.D., Chair of Hematology, Mayo Clinic, discusses updates that are expected in 2017 to the NCCN Guideline for myeloproliferative neoplasms (MPNs) on OncLive.com:


Dec. 4 at 10:30 a.m. PST

#ASH16 Audio Insights with Dong Chen, M.D., Ph.D.

One of this year's symposium highlights was Dr. Dong Chen's presentation, "Algorithmic Approaches to Laboratory Testing of von Willebrand Disease and Acquired von Willebrand Syndrome." We caught up with him on Friday morning to learn more:


Dec. 4 at 8:54 a.m. PST

Oral Presentations: Sunday, Dec. 4

Our colleagues from the Mayo Clinic Department of Laboratory Medicine and Pathology will be presenting the following oral presentations today:

Clinical Spectrum of Germline Mutations with Predisposition to Myeloid Neoplasms- 2016 World Health Organization Classification Update

Presenter: Thanh Ho, M.D.
Time and Location: 7:30 a.m.–9 a.m., Grand Hall C (Manchester Grand Hyatt San Diego)

Importance of Achieving Complete Remission (CR) after Intensive Therapy for Acute Myeloid Leukemia (AML) in Older Adults Age ≥60 Years: Analysis of Risk Factors for Early Mortality and Re-Induction, and Impact of Quality of Response on Overall Survival (OS) in the ECOG-ACRIN E2906 Randomized Trial

Presenter: James Foran, M.D.
Time and Location: 9:30 a.m.–11 a.m., Pacific Ballroom (Marriott Marquis San Diego Marina)

Pathogenesis of Myeloproliferative Disorders (A “Meet the Scientist” Program)

Presenter: Ayalew Tefferi, M.D.
Time and Location: 11:15 a.m.–12:15 p.m., Aqua Salon F (Hilton San Diego Bayfront)

Venetoclax Monotherapy for Relapsed/Refractory Multiple Myeloma: Safety and Efficacy Results from a Phase I Study

Presenter: Shaji Kumar, M.D.
Time and Location: 4:30 p.m.–6 p.m., Hall AB (San Diego Convention Center)


Dec. 3 at 5:30 p.m. PST

#ASH16 Day One Is in the Books

That's a wrap on Day 1 at #ASH16. Looking forward to Day 2.

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Dec. 3 at 3 p.m. PST

#ASH16 Audio Insights with William Nichols, M.D.

After our live symposium preceding #ASH16, we caught up with Dr. William Nichols for his thoughts about the symposium highlights and to learn more about his presentation, "Evaluation of Unexplained Prolonged APTT and PT." Listen below:


Dec. 3 at 11:08 a.m. PST

Oral Presentations: Saturday, Dec. 3

Our colleagues from the Mayo Clinic Department of Laboratory Medicine and Pathology will be presenting the following oral presentations today:

Exome Array Analyses Identify Low-Frequency Germline Variants Associated with Increased Risk of AML in a HLA-Matched Unrelated Donor Blood and Marrow Transplant Population

Presenter: Alyssa Clay, Ph.D.
Time and Location: 7:30 a.m.–9 a.m., San Diego Ballroom AB (Marriott Marquis San Diego Marina)

Myeloma: Management of the Newly Diagnosed High-Risk Patient

Presenter: Angela Dispenzieri, M.D.
Time and Location: 7:30 a.m.–9 a.m., Hall AB (San Diego Convention Center)

Gene Expression Profiling Identifies Distinct Signatures for Dysplastic and Proliferative Chronic Myelomonocytic Leukemia

Presenter: Mrinal Patnaik, M.B.B.S.
Time and Location: 9:30 a.m.–11 a.m., Grand Hall C (Manchester Grand Hyatt San Diego)

No Association of EBV or Immunosuppression Status with Outcomes in U.S. Patients with Diffuse Large B-Cell Lymphoma Treated in the Immunochemotherapy Era

Presenter: Sean Tracy, M.D., Ph.D.
Time and Location: 9:30 a.m.–11 a.m., Room 7AB (San Diego Convention Center)

Treatment and Clinical Outcomes of High Grade B-Cell Lymphomas with MYC and BCL2 and/or BCL6 Rearrangements (Double Hit/Triple Hit Lymphomas)

Presenter: Thomas Habermann, M.D.
Time and Location: Noon–1:30 p.m., Room 31 (San Diego Convention Center)

Correlation between Somatic Mutation Burden, Neoantigen Load, and Progression-Free Survival in Multiple Myeloma: Analysis of MMRF CoMMpass Study

Presenter: Amber Miller, Ph.D.
Time and Location: 2 p.m.–3:30 p.m., Grand Hall D (Manchester Grand Hyatt San Diego)

A Phase 1 Study of Nivolumab in Combination with Ipilimumab for Relapsed or Refractory Hematologic Malignancies (CheckMate 039)

Presenter: Stephen Ansell, M.D., Ph.D.
Time and Location: 2 p.m.–3:30 p.m., Room 6AB (San Diego Convention Center)

Nivolumab (Special Education Session on Newly Approved Drugs)

Presenter: Stephen Ansell, M.D., Ph.D.
Time and Location: 4 p.m.–5:30 p.m., Pacific Ballroom (Marriott Marquis San Diego Marina)


Dec. 3 at 11:08 a.m. PST

Day 1 #ASH16

We are excited to kick off Day 1 at #ASH16 in San Diego. The sunshine is bright, the weather is warm, and ASH attendees are in abundance! Our MML crew is ready and excited to meet everyone at booth #3613.

Left to right: Back row: Anne Wiktor, Andy Tofilon, Felipe Mendoza, Brent Westra, and Brian Button. Front row: Kelley Schreiber, Mary Bonnerup, Linda Leach, Sara Lassila, and Anita Workman.
Left to right: Back row: Anne Wiktor, Andy Tofilon, Felipe Mendoza, Brent Westra, and Brian Button.
Front row: Kelley Schreiber, Mary Bonnerup, Linda Leach, Sara Lassila, and Anita Workman.

Dec. 2 at 11:29 a.m. PST

Thank You to Our Faculty

A special thank you to our faculty members for their presentations during our pre-conference symposium:

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From left to right: William Nichols, M.D.; Aneel Ashrani, M.D.; John Heit, M.D.; Elona Turley, M.D., FRCPC; Dong Chen, M.D., Ph.D.; and Rajiv Pruthi, M.B.B.S.

Dec. 2 at 8:29 a.m. PST

Mayo Medical Laboratories Pre-Conference Symposium

Dr. Rajiv Pruthi delivers one of five presentations at this year's symposium.
Dr. Rajiv Pruthi delivers one of six presentations at this year's symposium.

Our Satellite Symposium preceding the 58th ASH Annual Meeting kicked off this morning. With a variety of presentations and discussion, the symposium is designed to inform participants about cost-effective, diagnostically efficient test-ordering strategies in hemostasis. Using test-ordering algorithms based on data derived from the Mayo Clinic Special Coagulation Laboratory practice and the literature, the symposium will illustrate how costly and unnecessary biochemical, phenotypic, and genetic testing can be avoided in the participants’ practices while enhancing highest quality medical care.

Participants have the opportunity to hear from our renowned faculty and enjoy the following presentations:

  • Evaluation of Unexplained Prolonged APTT and PT
  • Thrombophilia Testing: Who, When, How, and What’s Next?
  • Direct-Acting Anticoagulants: Practical Laboratory Aspects that Practicing Physicians Need to Know about
  • Algorithmic Approaches to Laboratory Testing of von Willebrand Disease and Acquired von Willebrand Syndrome
  • Lupus Anticoagulant: Overview of Laboratory Diagnosis and Case Studies
  • Malignancy-Associated Coagulopathy: Recognition and Laboratory Diagnosis
Dr. Dong Chen
Wrapping up the first half of the symposium, Dr. Dong Chen steps through, "Algorithmic Approaches to Laboratory Testing of von Willebrand Disease and Acquired von Willebrand Syndrome."
Dr. Rajiv Pruthi
Dr. Rajiv Pruthi delivers, "Direct-Acting Anticoagulants: Practical Laboratory Aspects that Practicing Physicians Need to Know about."
Elona Turley, M.D., FRCPC, discusses "Lupus Anticoagulant: Overview of Laboratory Diagnosis and Case Studies"
Elona Turley, M.D., FRCPC, discusses "Lupus Anticoagulant: Overview of Laboratory Diagnosis and Case Studies"
William Nichols, M.D., discussing "Evaluation of Unexplained Prolonged APTT and PT."
William Nichols, M.D., discussing "Evaluation of Unexplained Prolonged APTT and PT."
John Heit, M.D., discussing "Thrombophilia Testing: Who, When, How, and What’s Next?"
John Heit, M.D., discussing "Thrombophilia Testing: Who, When, How, and What’s Next?"
A "bird's eye" view from breakfast.
A "bird's eye" view from breakfast.
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego

#ASH16 Audio Insight: Looking forward to Our Symposium

Mayo Medical Laboratories will be hosting a Friday symposium preceding the 58th American Society of Hematology Annual Meeting. For the fourth straight year, we will bring together a diverse group of presenters. This year, the panel will discuss Algorithmic Approaches to Coagulopathy Testing. To learn more about this year's symposium, speakers, and subjects, we sat down with one of the course directors. Below is our brief interview with Rajiv Pruthi, M.B.B.S.:


 

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