The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Presence of Intraepithelial Food Antigen in Patients with Active Eosinophilic Oesophagitis
Although eosinophilic oesophagitis (EoE) is putatively mediated by an abnormal response to food antigen, the oesophagus is considered relatively impermeable to large molecules. Mayo Clinic researchers conducted a study to assess whether food antigens penetrate the oesophageal mucosa in patients with EoE. Patients with active EoE had significantly greater epithelial density of anti-gliadin staining when compared to inactive EoE and gluten-free patients at baseline and after soy infusion. Gliadin was not detected in non-EoE control patients. The distribution of gliadin was both cytoplasmic and nuclear. There was good correlation of dilated intercellular spaces grade and total gliadin staining intensity. Acute oesophageal perfusion of a commercial gliadin-rich soy sauce did not lead to an increase in gliadin staining in active or inactive EoE. These findings suggest, although do not prove, that antigen penetration in active eosinophilic oesophagitis might be facilitated by impairment of epithelial integrity. The case was published in Alimentary Pharmacology & Therapeutics.
Published to PubMed This Week
- Comprehensive Genomic Profiling of Central Giant Cell Lesions Identifies Clinically Relevant Genomic Alterations
Journal of Oral and Maxillofacial Surgery
- Potential Contribution of the Uterine Microbiome in the Development of Endometrial Cancer
- Tenosynovial Giant Cell Tumors of the Temporomandibular Joint and Lateral Skull Base: Review of 11 Cases
- Biological Variability of Lipoprotein-Associated Phospholipase A<sub>2</sub>Activity in Healthy Individuals
- Genetic Alterations Affecting GTPases and T-cell Receptor Signaling in Peripheral T-Cell Lymphomas