PathWays Case Study: Dec. 20

A 25-year-old presented with a lesion on the left elbow, which was thought to a be a subcutaneous cyst. The lesion had been present for at least one year prior to excision. Grossly, it appeared to be cystic with mixed areas of hemorrhage. Immunohistochemically, the tumor cells are positive for desmin and negative for CD34, CD31, AE1/AE3, S-100, SOX-10, and Alk. Also, FISH showed findings consistent with an EWSR1 gene rearrangement.

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Kyle Perry

Kyle Perry, M.D.
Fellow, Bone and Soft Tissue Pathology
Mayo Clinic

 

 

 

folpe_andrew_l_16apAndrew Folpe, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

 

 

 

renecre

Rene Revier

Rene Revier is an Editorial Assistant at Mayo Medical Laboratories. She supports Mayo Clinic PathWays and other corporate communications activities.

Responses

Very nice case and is also very important for educational purposes.

That was my initial DX but the mitoses and pos. desmin drew me into the wrong DX. Great case!

muy buena iniciativa, exelentes imàgenes, gracias muchas gracias.

EWSR1 helped to come to diagnosis , sometimes molecular diagnosis helps a lot know madam

Nice case. Interesting to note that not all EWSR1 gene rearrangements are necessarily associated with really bad behavior(!).

thank you for your educative case

Great case. I have a similar case but desmin was negative.

Very nice case… Thank u so much

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