The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Differential Gene Expression Profiling of Matched Primary Renal Cell Carcinoma and Metastases Reveals Upregulation of Extracellular Matrix Genes
The majority of renal cell carcinoma (RCC) studies analyze primary tumors, and the corresponding results are extrapolated to metastatic RCC tumors. However, it is unknown if gene expression profiles from primary RCC tumors differs from patient-matched metastatic tumors. Mayo Clinic researchers conducted a study to identify differentially expressed genes between patient-matched primary and metastatic RCC tumors in order to understand the molecular mechanisms underlying the development of RCC metastases. Researchers compared gene expression profiles between patient-matched primary and metastatic RCC tumors using a two-stage design. Affymetrix microarrays were assessed on 15 pairs of primary RCC (14 clear cell RCC, 1 papillary) tumors and patient-matched pulmonary metastases. Researchers also used custom Nanostring panel to validate seven candidate genes in an independent cohort of 114 clear cell RCC (ccRCC) patients. Researchers identified and validated up regulation of seven genes functionally involved in the formation of the extracellular matrix (ECM): DCN, SLIT2, LUM, LAMA2, ADAMTS12, CEACAM6 and LMO3. In primary ccRCC, CEACAM6, and LUM were significantly associated with metastasis-free and overall survival. The study implicates up regulation of ECM genes as a critical molecular event leading to visceral, bone, and soft tissue metastases in ccRCC. The study was published in Annals of Oncology.
Published to PubMed This Week
- Thrombotic Microangiopathy Associated with Monoclonal Gammopathy
- Brain tau Deposition Linked to Systemic Causes of Death in Normal Elderly
- Risk Stratification in Myeloma by Detection of Circulating Plasma Cells Prior to Autologous Stem Cell Transplantation in the Novel Agent Era
Blood Cancer Journal
- Improving Prediction of Postoperative Myocardial Infarction With High-Sensitivity Cardiac Troponin T and NT-proBNP
Anesthesia & Analgesia
- Cytotoxic T-cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women
Cancer Epidemiology, Biomarkers & Prevention
- Exposure of Bacterial Biofilms to Electrical Current Leads to Cell Death Mediated in Part by Reactive Oxygen Species
- A Robust and Efficient Feature Selection Algorithm for Microarray Data
- Exchange Transfusion for Babesiosis When, How, and How Long?
Indian Journal of Critical Care Medicine