Physicians, scientists, genetic counselors, and allied health staff from Mayo Clinic and Mayo Medical Laboratories are currently attending the American College of Cardiology (ACC) Annual Meeting in Washington, D.C.

In addition to being represented by numerous presentations and abstracts, Mayo Medical Laboratories representatives will be available at booth #2903 in the exhibit hall to discuss:

Cardiology Testing

EVIDENCE-BASED TESTING APPROACHES FOR CORRECT DIAGNOSES AND TREATMENT

Our unique combination of subspecialty laboratories and cardiology patient-care clinics has enabled the development of tests and testing approaches that have clinically proven outcomes and third-party validation showing reduced costs across an episode of care.

Resources:


Plasma Ceramides

A NOVEL BIOMARKER OF UNSTABLE ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Ceramides are complex lipids that play a central role in cell membrane integrity, cellular stress response, inflammatory signaling, and apoptosis. Synthesis of ceramides from saturated fats and sphingosine occurs in all tissues. Ceramides accumulate in tissues not suited for lipid storage during conditions of metabolic dysfunction and dyslipidemia. Three specific ceramides have been identified as highly linked to cardiovascular disease: Cer(16:0), Cer(18:0), Cer(24:1).

Resources:

Featured Poster Presentation:

March 18
3:45-4:30
Plasma Ceramide Concentrations Predict Risk of Cardiovascular Events


CV Pharmacogenomics Testing

MAXIMIZE EFFICACY AND MINIMIZE ADVERSE EVENTS OF COMMON CV THERAPIES

The drugs available today to treat cardiovascular disease are powerful agents that work as intended in most patients. Yet, in some people, a particular drug at the standard dose might not work well enough or may even trigger a serious adverse reaction. This can be due to genetic causes, which often play an important role in a patient’s predisposition to experiencing adverse drug reactions or therapeutic failure.

Resources:


CV Next-Generation Sequencing Panels

TESTING FOR CARDIOMYOPATHIES, NOONAN, LONG QT, BRUGADA, MARFAN SYNDROMES, AND RELATED DISORDERS

Next-generation sequencing (NGS) is a form of genetic analysis that allows the laboratory to analyze a large number of genes in a more efficient manner compared to other technologies. NGS technology has been increasingly used for a number of genetic conditions that display allelic and locus heterogeneity, such as cancer and inherited cardiac disorders.

Resources:


Mayo Clinic Presentations

ORAL CONTRIBUTIONS

March 17

5:30 p.m.–5:45 p.m.
913-06 - NPA7, a First in Class Dual Receptor Activator with Cardio-Renoprotective Properties In Vivo

914-06 - Scanning the Phenome to Uncover Pleiotropic Effects of PCSK9

6 p.m.–6:15 p.m.
915-08 - A Comparison of Kidney Function Decline in Atrial Fibrillation Patients Treated with Non-Vitamin K Antagonist Oral Anticoagulants or Warfarin

March 19

9:17 a.m.–9:27 a.m.
912-14 - Isolated Tricuspid Valve Surgery: Repair Versus Replacement

MODERATED POSTER CONTRIBUTIONS

March 17

10 a.m.–10:10 a.m.
1132M-03 - Impact of Aortic Valve Calcification and Sex on Hemodynamic Progression and Clinical Outcomes in Aortic Stenosis

10:30 a.m.–10:40 a.m. 
1134M-07 - CHA2DS2-VASc Score Predicts Incident Atrial Fibrillation/Flutter in a Referral Population

1131M-07 - Outcomes of Direct Current Cardioversion in Adults with Congenital Heart Disease

11 a.m.–11:10 a.m. 
1131M-11 - Outcomes of Non-Cardiac Procedures in Adult Fontan Patients

11:15 a.m.–11:25 a.m.
1139M-13 - The Addition of Renal Impairment to the CHA2DS2-VASc Score as a Predictor of Thromboembolism and Mortality in Patients without Atrial Fibrillation

11:30 a.m.–11:40 a.m.
1132M-15 - Coexisting Co-Morbidities Exacerbate Left Ventricular Diastolic Dysfunction and Prognosis in Patients with Severe Aortic Stenosis

3:45 p.m.–3:55 p.m.
1173M-03 - Digital Health Intervention Usage Improves Weight Loss in a Dose-Dependent Fashion

1171M-03 - Growth Dynamics of Aorta in Bicuspid Aortic Valve Patients from Infancy to Young Adult Age

March 18

10 a.m.–10:10 a.m.
1213M-05 - Wolff-Parkinson-White Pattern and Sudden Cardiac Death: A Retrospective Cohort Community Study from Olmsted County, Minnesota

1209M-05 - Gender Differences in Isolated Tricuspid Valve Surgery

1214M-05 - Postpartum and Pregnancy-Associated Spontaneous Coronary Artery Dissection: Presentation, Clinical Features ,and Outcomes

3:45 p.m.–3:55 p.m.
1260M-03 - Outcome of Anticoagulation Therapy for Bioprosthetic Valve Thrombosis: A Prospective Study

1267M-03 - Risk Factors Associated with Early- Versus Late-Accelerated Growth Patterns in Patients with Abdominal Aortic Aneurysm

4:15 p.m.–4:25 p.m.
1264M-07 - E/e’ Short- and Long-Term Independent Prognostic Role in Patients with Left Ventricular Dysfunction

1260M-07 - Poor Outcome of Thrombolysis in Right-Sided Mechanical Valve Thrombosis: Largest Single Center Experience

1267M-07 - Intracranial Aneurysms in Patients with Bicuspid Aortic Valve: Prevalence and Predictors of Occurence

March 19

9:45 a.m.–9:55 a.m.
1308M-03 - Chronic Right Ventricular Pacing: Effects on Heart Failure Hospitalization and Mortality in the Presence of Normal Left Ventricular Ejection Fraction

1309M-03 - Trends in Prevalence and In-Hospital Mortality of NSTEMI Patients with Solid Tumor Cancer: The Nationwide Analysis from 19982013

1303M-03 - Isolated Functional Tricuspid Regurgitation: A Population in Need of Treatment

10:15 a.m.–10:25 a.m.
1304M-07 - Familial Hypercholesterolemia: Awareness, Detection, and Control in the Community

1302M-07 - Outcomes of Cardiac Pacing in the Adult Fontan Population

12:45 p.m.–12:55 p.m.
1318M-05 - Sirolimus-Based Immunosuppression Mitigates Progression of Cardiac Allograft Vasculopathy and Improves Cardiac Outcomes after Heart Transplantation: A Single Center 15-Year Follow-Up Study

1:15 p.m.–1:25 p.m.
1319M-09 - Coronary Artery Disease Patients with Concurrent Psychiatric Disorders at Greater Risk for Mortality

1:30 p.m.–1:40 p.m.
1316M-11 - Long-Term Outcomes of Patients Undergoing Percutaneous and Surgical Mitral Paravalvular Leak Repair

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