The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Distinct Spatiotemporal Accumulation of N-Truncated and Full-Length Amyloid-β42 in Alzheimer's Disease
Accumulation of amyloid-β peptides is a dominant feature in the pathogenesis of Alzheimer's disease; however, it is not clear how individual amyloid-β species accumulate and affect other neuropathological and clinical features in the disease. Mayo Clinic researchers compared the accumulation of N-terminally truncated amyloid-β and full-length amyloid-β, depending on disease stage as well as brain area, and determined how these amyloid-β species respectively correlate with clinicopathological features of Alzheimer's disease. Retrospective review of clinical records showed that accumulation of N-terminally truncated amyloid-β42 in cortical areas was associated with disease onset, duration, and cognitive scores. Collectively, N-terminally truncated amyloid-β42 species have spatiotemporal accumulation patterns distinct from full-length amyloid-β42, likely due to different mechanisms governing their accumulations in the brain. These truncated amyloid-β species could play critical roles in the disease by linking other clinicopathological features of Alzheimer's disease. The study was published in Brain.
Published to PubMed This Week
- Clinical Manifestations and Outcomes of Fluoroquinolone-Related Acute Interstitial Nephritis
Mayo Clinic Proceedings
- Network-Directed Cis-Mediator Analysis of Normal Prostate Tissue Expression Profiles Reveals Downstream Regulatory Associations of Prostate Cancer Susceptibility Loci
- Urinalysis for the Diagnosis of Glomerulonephritis: Role of Dysmorphic Red Blood Cells
Nephrology Dialysis Transplantation
- Duration of Group A Streptococcus PCR Positivity Following Antibiotic Treatment of Pharyngitis
Diagnostic Microbiology and Infectious Disease
- Seeing is Believing: A Review of Apheresis Therapy in the Treatment of Ophthalmologic Disease
Journal of Clinical Apheresis
- Comparison Between Total IgG, C1q, and C3d Single Antigen Bead Assays in Detecting Class I Complement-Binding Anti-HLA Antibodies