Anatomic Pathology Case Study

​A 46-year-old woman presented for surgical management of endometriosis and underwent a total hysterectomy and bilateral salpingo-oophorectomy. In addition to typical-appearing leiomyomata, a well-circumscribed, soft, yellow tumor was identified.


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Amy A. Swanson, M.D.
Resident, Anatomic Pathology/Neuropathology
Mayo Clinic

 

 

schoolmeester_john_k_15jlJ. Kenneth Schoolmeester, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

Liver Pathology Case Study

This case study reviews a ​24-year-old man with a large solitary liver mass.

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Nooshin Karamzadeh Dashti, M.D.
Fellow, Surgical Pathology
Mayo Clinic
Rondell Graham, M.B.B.S.
Senior Associate Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Hematopathology Case Study #1

A 70-year-old female presented with peripheral blood lymphocytosis and hepatosplenomegaly. Below are the peripheral blood and bone marrow aspirate findings:

Karyotype cytogenetics revealed inv(14)(q11q32), with the rearrangement involving the TCL1 oncogene (confirmed by FISH).

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  Basma Basha, M.D.
Fellow, Hematopathology
Mayo Clinic
  Rebecca L. King, M.D.
Consultant, Division of Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

Hematopathology Case Study #2

A 49-year-old HIV-positive gentleman presents to his local medical center with cervical lymphadenopathy without a known associated pleural effusion. A needle core biopsy is performed. Within the perinodal soft tissue (top of Figure 1A), there is an atypical infiltrate of large pleomorphic cells (Figure 1). These cells do not express cytokeratin (Cam 5.2 or OSCAR), SOX10, CD3, CD20, CD30, CD45, or CD79a. These cells do express CD43, CD138, and MUM1 (Figure 2). Both in situ hybridization studies for Epstein-Barr virus (EBV) and an immunohistochemical stain for human herpes virus 8 (HHV-8) are positive (Figure 3).

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Justin Juskewitch, M.D., Ph.D.
Resident, Anatomic/Clinical Pathology
Mayo Clinic
Karen Rech, M.D.
Consultant, Division of Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

More PathWays Cases
View the PathWays Case Studies archives page to view a list of past cases.