Biotin and Laboratory Testing: Recognizing Interferences and Preventing Misdiagnosis

Expires: February 8, 2020

Presentation

Video Length - 53 minutes 43 seconds

Overview

Biotin is a water-soluble B complex vitamin found in a number of over-the-counter hair, skin, and nail supplements and multivitamins. Recent studies and case reports have shown that the presence of exogenous biotin in patient blood samples can interfere with some immunoassay-based laboratory testing. Physicians, patients, and laboratorians should be aware of the potential for erroneous test results due to biotin consumption as many FDA-cleared automated immunoassays use biotin-streptavidin interactions in their assay design. This presentation addresses current trends in biotin consumption and discusses practical strategies for clinical laboratories to prevent misdiagnosis and mitigate patient safety risks from biotin interference.

Objectives

Upon completion of this activity, participants should be able to:

  • Describe trends in biotin supplementation for therapeutic and nutraceutical purposes.
  • Recognize the potential impact of biotin consumption on some immunoassay-based laboratory test results.
  • Develop strategies to prevent misdiagnosis and mitigate patient safety risks from biotin interferences in lab testing.

Intended Audience

Fellows, general practitioners, microbiologists, nurses, nurse practitioners, physicians, physician assistants, residents, and surgeons.

Faculty

Image of Nikola Baumann, Ph.D.Nikola Baumann, Ph.D.
Consultant
Department of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, Minnesota

 

Image of Brooke Katzman, Ph.D.Brooke Katzman, Ph.D.
Mayo Clinic Scholar
Department of Laboratory Medicine and Pathology
Mayo Clinic
Rochester, Minnesota

Credit

The following types of credit are offered for our "Virtual Lecture" programs:
ASCLS P.A.C.E.®
State of California
State of Florida

To obtain credit:

  1. Watch the video.
  2. Complete the post-test and evaluation that launches immediately following the video.
  3. Generate and print your certificate.

For an instruction sheet that describes the process, view http://www.cme-evaluations.com/instructions.pdf.

ASCLS P.A.C.E.®

Mayo Medical Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E. ® program. This program has been approved for a maximum of 1.0 P.A.C.E® contact hour. Level of instruction for this program is intermediate.

State of California

Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Sciences for State of California. The level of instruction for this program is intermediate. This program has been approved for 1.0 contact hour.

State of Florida

Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for the clinical laboratory sciences for the State of Florida. Florida Board of Clinical Laboratory Personnel has designated this program for General credit. The level of instruction for this program is intermediate. This program has been approved for 1.0 contact hour.

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This post was developed by our Education and Technical Publications Team.