ASH 2016 Symposium Hero

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DECEMBER 2, 2016

Manchester Grand Hyatt San Diego
Coronado Ballroom
San Diego, California

Preceding the 58th American Society of Hematology (ASH) Annual Meeting

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This program’s overall objective is to inform participants about cost-effective, diagnostically efficient test-ordering strategies in hemostasis.

Using test-ordering algorithms based on data derived from the Mayo Clinic Special Coagulation Laboratory practice and the literature, we will illustrate how costly and unnecessary biochemical, phenotypic, and genetic testing can be avoided in the participants’ practices while enhancing highest quality medical care.


  • Hematologists
  • Oncologists
  • Pathologists
  • Nurse Practitioners
  • Physician Assistants
  • Nurses
  • Laboratory Scientists


Upon completion of the conference, participants should be able to:

  • Identify effective laboratory testing strategies for evaluating prolonged activated partial thromboplastin time (APTT) and/or prothrombin time (PT).
  • Recognize the limitations of laboratory testing and effects of direct acting anticoagulants on commonly ordered coagulation assays.
  • Discuss an algorithmic approach to diagnose both von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS).
  • Apply lupus anticoagulant testing results to the diagnosis of clinical cases.
  • Identify the appropriate indications, timing, and repertoire of thrombophilia testing, and the potential future role of thrombophilia testing.

Attendance at this Mayo conference does not indicate nor guarantee competence or proficiency in the performance of any procedures that may be discussed or taught in the courses.


7:00–7:25 a.m. Pre-Conference Check-In/Registration
7:25–7:30 Introduction

7:30–8:00 Evaluation of Unexplained Prolonged APTT and PT
(view slides)
William Nichols, M.D.
8:00–8:30 Thrombophilia Testing: Who, When, How, and What’s Next? (view slides) John Heit, M.D.
8:30–9:00 Direct-Acting Anticoagulants: Practical Laboratory Aspects That Practicing Physicians Need to Know About (view slides)

Rajiv Pruthi, M.B.B.S.
9:00–9:30 Algorithmic Approach to Laboratory Testing of von Willebrand Disease and Acquired von Willebrand Syndrome (view slides)

Dong Chen, M.D., Ph.D.
9:30–9:50 Refreshment Break
9:50–10:20 Lupus Anticoagulant: Overview of Laboratory Diagnosis and Case Studies (view slides)

Elona Turley, M.D., FRCPC
10:20–10:50 Malignancy-Associated Coagulopathy: Recognition and Laboratory Diagnosis (view slides)

Aneel Ashrani, M.D.
10:50 a.m. Adjourn


Mayo Clinic College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Mayo Clinic College of Medicine designates this live activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Mayo Medical Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® Program. This program has been approved for 3 P.A.C.E. contact hours. Level of instruction for this program is intermediate.

Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Sciences for State of California and State of Florida credit. Florida Board of Clinical Laboratory Personnel has designated this program for Hematology credit. Level of instruction for this program is intermediate. This program has been approved for 3 contact hours.


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Aneel Ashrani, M.D.-pic
Aneel Ashrani, M.D.- bio
Dong Chen, M.D., Ph.D. - pic
Dong Chen, M.D., Ph.D. - bio
John Heit, M.D. - pic
John Heit, M.D. - bio
William Nichols, M.D. - pic
William Nichols, M.D. - bio
Rajiv Pruthi, M.B.B.S. - pic
Rajiv Pruthi, M.B.B.S. - bio
Elona Turley, M.D., FRCPC - pic
Elona Turley, M.D., FRCPC - bio


As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity, and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty members also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentations. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentations.


Mayo Clinic College of Medicine complies with the requirements of the National Physician Payment Transparency Program OPEN PAYMENTS (Physician Payments Sunshine Act).