Greg Widseth was suddenly hit by a rare disease that prompted his immune system to attack his brain cells, resulting in as many as 60 seizures a day. Special blood and spinal fluid tests developed by Mayo Medical Laboratories confirmed that Widseth had antibodies known to target certain brain cells.
Recently, a team of researchers and physicians at Mayo Clinic in Rochester identified a new type of renal amyloidosis derived from the protein apolipoprotien C-II (Apo-CII).
Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders categorized under chronic myeloid malignancies. In this publication, we share our 25 years of experience with primary MDS patients who were evaluated and treated at Mayo Clinic.
Helicobacter pylori (H pylori) infection is among the most common bacterial infections worldwide with approximately one-half of the world’s population infected. Several invasive and noninvasive testing methods are available to detect H pylori infection.
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker of atherosclerosis and is often referred to by the trademark name “The PLAC Test.” Lp-PLA2 is an enzyme involved with atherosclerotic plaque formation and elevations in plasma Lp-PLA2 concentration and activity are associated with increased risk of cardiovascular disease.
Accurate matching of patients with appropriate blood units is imperative for safe blood transfusion practice. In theory, a computerized bar code-based blood identification system should result in a reduction in transfusion errors.
Inherited cardiovascular diseases have historically been identified most frequently through the patient’s family history. Now, next-generation sequencing technology has taken genetic testing to a new level, allowing assessment of multiple genes and mutations with one test.
Serum thyroglobulin concentrations are used to monitor patients with differentiated thyroid cancer, but may be misleading in the presence of antithyroglobulin autoantibodies and heterophile antibodies. Mayo Medical Laboratories has developed an assay to address this issue by testing first for the presence of thyroglobulin antibodies by immunoassay and, in antibody-positive specimens.
The porphyrias are a group of inborn errors of metabolism caused by enzymatic defects in the heme biosynthetic pathway. Depending upon the specific type of porphyria suspected, certain tests are more informative than other assays.
In 2012, southeastern Minnesota experienced its largest local pertussis outbreak in recent history. In this article, we report the epidemiology and clinical and microbiological characteristics of the pertussis outbreak and examine possible contributing factors.
Lupus anticoagulants are associated with thrombosis, recurrent fetal loss, neurological problems, and cutaneous manifestations. Accurate diagnosis is important considering the potential use of long-term anticoagulant therapy because of the high risk of recurrent thrombosis.
Waldenström macroglobulinemia is a rare disease. Patients present with a spectrum of clinical findings, and many patients do not require treatment initially. This article describes a risk-adapted approach with recommendations on timing and choice of therapy.