Endocrinology

View this week’s case study by Justin Juskewitch, M.D., Ph.D.; Mariam (Priya) Alexander, M.D.; and Michael Torbenson, M.D., and make your diagnosis.

By Rene Revier • February 14, 2017

This week’s Research Roundup highlights thyroid hormone treatment among pregnant women with subclinical hypothyroidism.

By Kelley Schreiber • January 30, 2017

Fibrolamellar carcinoma is a rare subtype of primary liver cancer, and the diagnosis can sometimes be difficult. A new test, developed at Mayo Clinic, uses FISH technology to identify the fusion gene DNAJB1-PRKACA, reported in fibrolamellar carcinomas.

By MML Education • December 5, 2016

Vitamin D is essential for the metabolism and stable equilibrium of calcium and phosphate—elements that are necessary for the growth and development of bones and teeth. Vitamin D also aids in the normal functioning of the body’s nervous system. However, in this era of increased supplementation, there is growing evidence that individuals may be at risk of vitamin D toxicity as a result of overdosing.

By Kelley Schreiber • April 4, 2016

There has been significant interest in identifying those patients at risk of vitamin D deficiency. However, in this era of increased supplementation, there is growing evidence that individuals may be at risk of vitamin D toxicity as a result of overdosing. The use of multiple products that contain vitamin D supplementation can combine to potentially toxic levels.

By MML Education • November 2, 2015

In the first comprehensive review article of its kind, a Mayo Clinic fertility consultant describes how evidence for the importance of air quality in clinical embryology laboratories—in particular, the role of volatile organic compounds—has resulted in an evolution of clinical practice that has contributed to improved outcomes. The review was published in the Journal of Assisted Reproduction and Genetics.

By Kelley Schreiber • October 5, 2015

To establish the potential impact of mass spectrometry-based Tg quantification on patient care, Mayo Clinic researchers performed a comprehensive analytical and clinical evaluation of immunoassays in thyroid cancer patients. The study, published in the Journal of Clinical Endocrinology and Metabolism, allowed researchers to assess the performance of different serum thyroglobulin assays in the presence of anti-thyroglobulin auto-antibodies.

By Kelley Schreiber • September 8, 2015

Serum thyroglobulin concentrations are used to monitor patients with differentiated thyroid cancer, but may be misleading in the presence of antithyroglobulin autoantibodies and heterophile antibodies. Mayo Medical Laboratories has developed an assay to address this issue by testing first for the presence of thyroglobulin antibodies by immunoassay and, in antibody-positive specimens.

By Communiqué Archive • May 1, 2015

Serum thyroglobulin (Tg) measurement is used as a follow-up test for patients with differentiated follicular cell-derived thyroid carcinoma after surgical removal of the thyroid. The Mayo Clinic Endocrine Laboratory has developed an assay that allows accurate quantification of Tg in patients with antithyroglobulin autoantibodies or heterophile antibodies.

By Kelley Schreiber • May 1, 2015

Serum thyroglobulin measurement is useful in the follow-up of patients with differentiated follicular cell-derived thyroid carcinoma. After removal of the thyroid gland, thyroglobulin concentrations should be undetectable or very low. The presence of anti-thyroglobulin autoantibodies, which occur in 15 to 30 percent of thyroid cancer patients, could lead to inaccurate quantitation of thyroglobulin. Recently, trypsin digestion of serum proteins has allowed accurate quantification of Tg by mass spectrometry.

By MML Education • April 1, 2015

This new Mayo Clinic assay provides clinicians an accurate measurement of serum thyroglobulin in patients with known or suspected anti-thyroglobulin autoantibodies or heterophilic antibodies. View a quick overview of the test’s details and a five-minute video interview with Dr. Stefan Grebe.

By Kelley Schreiber • April 8, 2014

Serum thyroglobulin testing using SISCAPA® technology and liquid chromatography, tandem mass spectrometry now performed at Mayo Medical Laboratories.

By Andy Tofilon • April 7, 2014

Should physicians and researchers, policy makers or the public want to know about diabetes in Minnesota, or available health care options, it’s now just a click away. The Minnesota Health Atlas is an online series of maps showing county-by-county data, focused to help the state’s diabetic population. It is a unique resource, not available elsewhere in the country. Read more to learn about the Atlas as well as diabetes testing information.

By Mayo Medical Laboratories • November 13, 2012